Reduce the Frequency of Migraine Headaches
Petadolex® The Safe Form
of Butterbur
- Made with 75 mg of Petadolex Butterbur
- Backed by decades of research and real-world use
- The Butterbur extract recommended by The Canadian Headache Society
- Herbal softgel capsules
- Suitable for Adults
Petadolex® 75 mg
Helps to reduce the frequency of migraine headaches when taken preventatively/as a prophylactic.
- Made with 75 mg of Petadolex Butterbur
- Backed by decades of research and real-world use
- The Butterbur extract recommended by The Canadian Headache Society
- Herbal softgel capsules
- Suitable for Adults
- Off brand butterbur products may contain toxic alkaloids
- Off brand butterbur products don’t always contain enough active ingredients to treat & prevent migraine headaches
- Off brand butterbur products might not be as effective to prevent the frequency of migraine headaches
Butterbur (Petasites hybridus) is a shrub native to Europe and temperate parts of Asia. Extracts from the leaves and roots of the butterbur plant have been used for centuries as medicine for respiratory conditions, headache, and cramps in the urinary and digestive tract.
Butterbur is one of nature’s most effective herbal extracts to help reduce the frequency of migrane headaches when taken preventatively.
Petasites hybridus root (butterbur) is an effective preventive treatment for migraine
R B Lipton 1, H Göbel, K M Einhäupl, K Wilks, A Mauskop
Key findings: The results suggest that migraine patients can benefit from prophylactic treatment with this special extract. The combination of high efficacy and excellent tolerance emphasizes the particular value that Petasites hydridus has for the prophylactic treatment of migraine.
Safety profile of a special butterbur extract from Petasites hybridus in migraine prevention with emphasis on the liver
HC Diener1 , FG Freitag2 , and U Danesch3
Key Findings: Only a proprietary root extract of P. hybridus (Petadolex) is well characterized and the only extract with a proven clinical efficacy in migraine prevention. Unlike some other butterbur extracts in the market, Petadolex is free of detectable levels of PAs.
An extract of Petasites hybridus is effective in the prophylaxis of migraine
M Grossmann 1, H Schmidramsl
Key Findings: Clinical results suggest that migraine patients can benefit from prophylactic treatment with the special extract, Petadolex with excellent tolerability.
Petasites for Migraine Prevention: New Data on Mode of Action, Pharmacology and Safety. A Narrative Review
Jürgen Borlak,corresponding author 1 , * Hans-Christoph Diener, 2 Johanna Kleeberg-Hartmann, 3 Karl Messlinger, 3 and Stephen Silberstein 4
Key findings: Butterbur is effective in the prevention of migraine attacks, and recent research is highly suggestive for a mechanism whereby petasins block CGRP nociceptive pathways. However, only one product (Petadolex®) was extensively evaluated in preclinical and clinical studies in migraine to demonstrate therapeutic efficacy and safety.
The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria
H C Diener 1, V W Rahlfs, U Danesch
Key Findings: The responder rate (improvement of migraine frequency > or =50%) was 45% in the verum group and 15% in the placebo group. Butterbur was well tolerated. This small trial indicates that butterbur may be effective in the prophylaxis of migraine.
Announcement
As of September 1st, 2023 Petadolex 75 mg is exclusively distributed in Canada by Pascoe Canada Inc.